These metrics are regularly updated to reflect usage leading up to the last few days. Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts. The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric. Find more information on the Altmetric Attention Score and how the score is calculated. The increase in accuracy for the NDDO-based methods is relatively modest due to the random errors in predicted heats for formation.
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Access anywhere, on your desktop and online. Download. people_alt Sahoo, B. M.; Dinda, S. C.; Ravi Kumar, B. V.V.; Panda, J.; Brahmkshatriya, P. S. Lett. Drug Des. Discovery , 11, 82– Dates. Publication Date: August 13,
Shah, S. Savle, M. Rathod, C. Shishoo and P. College of Pharmacy, Navrangpura, Ahmedabad , India. A sensitive and specific high performance thin layer chromatographic method has been developed for estimation of a novel antihyperlipidemic agent LM in rabbit plasma and its use for pharmacokinetic study has been evaluated. The proposed method was employed to study pharmacokinetics of LM in rabbits.
It was observed that LM metabolized immediately after oral administration. Biological screening of LM C on hyperlipidemic rats indicated that it is less potent than the parent compound which is indicative of biotransformation of LM to active form LM C. N-Cyanovmylamidine a useful intermediate for pyridine synthesis have been successfully isolated from our laboratory [ 1 ]. Earlier, we have reported synthesis and antihyperlipidemic activity in a series of novel N-cyanovinyl formamidines, where some of the compounds were found to possess potent antihyperlipidemic activity [ 2 ].
Among these compounds, N-[2-carbethoxycyano pchloroanilino vinyl]formamidine, LM fig. Acute toxicity study of LM has shown no mortality or behavioral changes in mice after oral administration up to the dose of 4.
Meta-analysis of gene expression in relapsed childhood B-acute lymphoblastic leukemia.
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DOI: ; Published online by Donker, J. D., Naik, D. J., Brahmakshatriya, R. D., Maclure, F. A. & Marten, G. C. ().
Continue to access RSC content when you are not at your institution. Follow our step-by-step guide. Acquired immunodeficiency syndrome AIDS is a life-threatening disease which is a collection of symptoms and infections caused by a retrovirus, human immunodeficiency virus HIV. There is currently no curative treatment and therapy is reliant on the use of existing anti-retroviral drugs. Pharmacoinformatics approaches have already proven their pivotal role in the pharmaceutical industry for lead identification and optimization.
In the current study, we analysed the binding preferences and inhibitory activity of HIV-integrase inhibitors using pharmacoinformatics. A set of 30 compounds were selected as the training set of a total molecules for pharmacophore model generation. The final model was validated by statistical parameters and further used for virtual screening.
From virtual screening, initial hits were sorted using a number of parameters and finally two compounds were proposed as promising HIV-integrase inhibitors.
Metrics details. Free-ranging chickens are often infected with Toxoplasma gondii and seroconvert upon infection. This indicates environmental contamination with T. Recombinant biotinylated T.
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J Control Release. Epub Nov Epub Jan PLoS One. Sci Rep. Replens prevents preterm birth by decreasing type I interferon strengthening the cervical epithelial barrier. Am J Reprod Immunol. Epub Oct Bioactive polymeric materials and electrical stimulation strategies for musculoskeletal tissue repair and regeneration. Bioact Mater.
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From Wikipedia, the free encyclopedia. In the Hindu varna system, Brahmakshatriya may refer to a Brahmin who pursues royalty, and hence concurrently adopts the Kshatriya varna or those Kshatriya who had adopted Brahmin varna because of Parashurama. According to Manusmriti , such people are treated equal to Brahmins.
In Kerala, only the sons of a Nambuthiri father and a Kshatriya mother were recognised as Brahmakshatriya by the Nambuthiri Brahmins, while the son of a Brahmakshatriya father and a non-Kshatriya mother was regarded as non-Kshatriya.
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T cell development requires a period of postthymic maturation. We now show that the first few weeks of T cell residence in the lymphoid periphery define a period of heightened susceptibility to tolerance induction to tissue-restricted antigens TRAs , the outcome of which depends on the context in which recent thymic emigrants RTEs encounter antigen. After encounter with TRAs in the absence of inflammation, RTEs exhibited defects in proliferation, diminished cytokine production, elevated expression of anergy-associated genes, and diminished diabetogenicity.
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Fresh produce, such as lettuce and spinach, serves as a route of food-borne illnesses. The U. FDA has approved the use of ionizing irradiation up to 4 kGy as a pathogen kill step for fresh-cut lettuce and spinach. The focus of this study was to determine the inactivation of poliovirus and rotavirus on lettuce and spinach when exposed to various doses of high-energy electron beam E-beam irradiation and to calculate the theoretical reduction in infection risks that can be achieved under different contamination scenarios and E-beam dose applications.
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Natural Products pp Cite as. Terpenoids are naturally occurring hydrocarbons produced by a wide variety of plants and animals. They are classified based on five-carbon isoprene units as their building blocks, numbering more than 55, molecules having been discovered till date. Diverse functional roles of terpenoids have been critically studied and well-accepted now. Some of them include natural flavor additives for food or fragrances in perfumery and in traditional and alternate medicines as aromatherapy.
Biosynthetically, terpenoids are formed via two major synthetic pathways: mevalonic acid MVA pathway and 2 C -methyl-D-erythritolphosphate MEP pathway. Biologically active terpenoids span various orders of magnitude. Most comprehensively studied of which is the effect of terpenes in prevention and treatment of cancer. Illustratively, Taxol derivative paclitaxel and docetaxel are among the widely used drugs in cancer chemotherapy. Other important therapeutic uses of terpenoids include antimicrobial, antifungal, antiviral, antihyperglycemic, anti-inflammatory, antioxidants, antiparasitic, immunomodulatory, and as skin permeation enhancer.